Search Clinical Trials
Sponsor Condition of Interest |
---|
DM-CHOC-PEN for Brain Tumors in AYA Subjects
DEKK-TEC, Inc.
Advanced Cancer
Brain Metastases
4-Demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) is a polychlorinated pyridyl
cholesterol carbonate that is lipophilic, electrically neural, crosses the blood brain
barrier (BBB), ability to localize in intracranial tumor tissue, lacks neurotoxicity and not
transported... expand
4-Demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) is a polychlorinated pyridyl cholesterol carbonate that is lipophilic, electrically neural, crosses the blood brain barrier (BBB), ability to localize in intracranial tumor tissue, lacks neurotoxicity and not transported out of the brain via Pgp (p-glycoprotein). DM-CHOC-PEN has completed a Phase I Adolescent and Young Adult (AYA) trial in humans, some of which possessed primary and secondary tumors involving the brain. Complete remissions in both primary (astrocytoma, GBM) and metastatic lung cancers were reported. This Phase II trial is open for adolescent and young adults (AYA) subjects with advanced cancer - brain involvement is required. Type: Interventional Start Date: Jan 2019 |
Telmisartan Plus Exercise to Improve Functioning in Peripheral Artery Disease
Northwestern University
Peripheral Artery Disease
The TELEX trial will establish whether telmisartan alone improves walking performance in
people with peripheral artery disease (PAD). The TELEX trial will also determine whether
telmisartan plus supervised exercise improves walking performance more than either therapy
alone.... expand
The TELEX trial will establish whether telmisartan alone improves walking performance in people with peripheral artery disease (PAD). The TELEX trial will also determine whether telmisartan plus supervised exercise improves walking performance more than either therapy alone. TELEX is a randomized controlled clinical trial (2 x 2 factorial design) of 112 participants with PAD randomized to one of four arms: Group A: telmisartan + supervised exercise therapy; Group B: telmisartan + a "no exercise" control group; Group C: placebo + supervised exercise therapy; and Group D: placebo + a "no exercise" control group. Type: Interventional Start Date: Oct 2015 |
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)
Center for International Blood and Marrow Transplant Research
Hematologic Malignancies
Inherited Disorders of Metabolism
Inherited Abnormalities of Platelets
Histiocytic Disorders
Acute Myelogenous Leukemia (AML or ANLL)
This study is an access and distribution protocol for unlicensed cryopreserved cord blood
units (CBUs) in pediatric and adult patients with hematologic malignancies and other
indications.
expand
This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic malignancies and other indications. Type: Observational Start Date: Oct 2011 |
Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer
ECOG-ACRIN Cancer Research Group
Breast Screening
This randomized phase III trial studies digital tomosynthesis mammography and digital
mammography in screening patients for breast cancer. Screening for breast cancer with
tomosynthesis mammography may be superior to digital mammography for breast cancer screening
and may... expand
This randomized phase III trial studies digital tomosynthesis mammography and digital mammography in screening patients for breast cancer. Screening for breast cancer with tomosynthesis mammography may be superior to digital mammography for breast cancer screening and may help reduce the need for additional imaging or treatment. Type: Interventional Start Date: Jul 2017 |
The Effect of Music Therapy on Newborns
Tulane University
Neonatal Abstinence Syndrome
Substance Withdrawal, Neonatal
The clinical study is evaluating the impact of music therapy on neonates, specifically
infants with neonatal opioid withdrawal syndrome (NOWS). The goal is to study the effect of
music therapy on an infant's behavioral (i.e feeding patterns, sleep patterns, severity of
withdrawal)... expand
The clinical study is evaluating the impact of music therapy on neonates, specifically infants with neonatal opioid withdrawal syndrome (NOWS). The goal is to study the effect of music therapy on an infant's behavioral (i.e feeding patterns, sleep patterns, severity of withdrawal) and physiological systems (i.e. heart rate, respiratory rate). The investigators are also studying the impact of music therapy on the infant's utilization of resources (i.e. total opioid usage and total length of stay). Type: Interventional Start Date: Dec 2018 |
Study of Ibrutinib and Rituximab in Treatment Naïve Follicular Lymphoma
Pharmacyclics LLC.
Follicular Lymphoma
The purpose of this study is to evaluate whether the addition of ibrutinib will result in
prolongation of progression-free survival (PFS) when compared with rituximab alone in
treatment naïve subjects with follicular lymphoma.
expand
The purpose of this study is to evaluate whether the addition of ibrutinib will result in prolongation of progression-free survival (PFS) when compared with rituximab alone in treatment naïve subjects with follicular lymphoma. Type: Interventional Start Date: Jan 2017 |
Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive...
Alliance for Clinical Trials in Oncology
Stage II Breast Cancer
Stage IIIA Breast Cancer
This randomized phase III trial studies lymph node dissection and radiation therapy to see
how well it works compared to radiation therapy alone in treating patients with breast cancer
previously treated with chemotherapy and surgery. Lymph node dissection may remove cancer... expand
This randomized phase III trial studies lymph node dissection and radiation therapy to see how well it works compared to radiation therapy alone in treating patients with breast cancer previously treated with chemotherapy and surgery. Lymph node dissection may remove cancer cells that have spread to nearby lymph nodes in patients with breast cancer. Radiation therapy uses high-energy x rays or protons to kill tumor cells. It is not yet known if radiation therapy works better alone or with lymph node dissection in treating patients with breast cancer previously treated with chemotherapy and surgery. Type: Interventional Start Date: Feb 2014 |
Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet to Assess Change in Spleen...
AbbVie
Myelofibrosis (MF)
Myelofibrosis (MF) is a bone marrow illness that affects blood-forming tissues in the body.
MF disturbs the body's normal production of blood cells, causing extensive scarring in the
bone marrow. This leads to severe anemia, weakness, fatigue, and an enlarged spleen. The
purpose... expand
Myelofibrosis (MF) is a bone marrow illness that affects blood-forming tissues in the body. MF disturbs the body's normal production of blood cells, causing extensive scarring in the bone marrow. This leads to severe anemia, weakness, fatigue, and an enlarged spleen. The purpose of this study is to assess safety and change in spleen volume when navitoclax is given in combination with ruxolitinib, as compared to best available therapy, for adult participants with MF. Navitoclax is an investigational drug (not yet approved) being developed for the treatment of MF. The study has 2 arms - A and B. In Arm A, participants will receive navitoclax in combination with ruxolitinib. In Arm B, participants will receive the best available therapy (BAT) for MF. Adult participants with a diagnosis of relapsed/refractory (R/R) MF will be enrolled. Approximately 330 participants will be enrolled in approximately 190 sites across the world. In Arm A, participants will receive oral navitoclax tablet once daily with oral ruxolitinib tablet twice daily. In Arm B, participants will receive the BAT as identified by the investigator. Treatment will continue until clinical benefit is not seen, participants cannot tolerate the study drugs, or participants withdraw consent. The approximate treatment duration is about 3 years. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of treatment will be checked by medical assessments, blood and bone marrow tests, checking for side effects, and completing questionnaires. Type: Interventional Start Date: Aug 2020 |
NCI COVID-19 in Cancer Patients, NCCAPS Study
National Cancer Institute (NCI)
COVID-19 Infection
Hematopoietic and Lymphoid Cell Neoplasm
Malignant Solid Neoplasm
Metastatic Malignant Solid Neoplasm
This study collects blood samples, medical information, and medical images from patients who
are being treated for cancer and have a positive test for SARS CoV-2, the new coronavirus
that causes the disease called COVID-19. Collecting blood samples, medical information, and... expand
This study collects blood samples, medical information, and medical images from patients who are being treated for cancer and have a positive test for SARS CoV-2, the new coronavirus that causes the disease called COVID-19. Collecting blood samples, medical information, and medical images may help researchers determine how COVID-19 affects the outcomes of patients undergoing cancer treatment and how having cancer affects COVID-19. Type: Observational Start Date: May 2020 |
Use of Death Cafes to Prevent Burnout in ICU Healthcare Employees
Tulane University School of Medicine
Burnout
Burnout, Professional
Burnout, Psychological
Anxiety
Depression
Burnout affects a significant number of healthcare employees and leads to worsened mental
health, increased job turnover, and patient safety events. Those caring for critically ill
patients may be especially susceptible due to high patient mortality, long hours, and regular... expand
Burnout affects a significant number of healthcare employees and leads to worsened mental health, increased job turnover, and patient safety events. Those caring for critically ill patients may be especially susceptible due to high patient mortality, long hours, and regular encounters with traumatic and ethical issues. Preliminary studies suggest that debriefing opportunities may reduce burnout through reflection on distressing patient events, enhancement of social support, and interprofessional collaboration. Death Cafés are a specific form of debriefing that focus on discussing death, dying, loss, and illness. The purpose of this study is to evaluate whether biweekly Death Cafe group debriefing sessions can prevent burnout in ICU physicians and staff. Type: Interventional Start Date: Jul 2020 |
Study to Evaluate the Efficacy and Safety of CC-90001 in Subjects With Non-alcoholic Steatohepatitis...
Celgene
Non-alcoholic Fatty Liver Disease
Liver Cirrhosis
This is a Phase 2, randomized, double-blind, placebo-controlled, multicenter, multinational,
dose-finding study evaluating the efficacy of three treatment doses of CC-90001 (100 mg, 200
mg and 400 mg PO QD), compared with placebo, in NASH subjects with Stage 3 and Stage 4... expand
This is a Phase 2, randomized, double-blind, placebo-controlled, multicenter, multinational, dose-finding study evaluating the efficacy of three treatment doses of CC-90001 (100 mg, 200 mg and 400 mg PO QD), compared with placebo, in NASH subjects with Stage 3 and Stage 4 fibrosis. This study is designed to assess response to treatment on measures of fibrosis and other efficacy parameters. It will also assess dose response and overall safety. Type: Interventional Start Date: Aug 2019 |
A Clinical Study to Test How Effective and Safe GLPG1690 is for Subjects With Idiopathic Pulmonary Fibrosis...
Galapagos NV
Idiopathic Pulmonary Fibrosis
The main purpose of this study is to see how GLPG1690 works together with your current
standard treatment on your lung function and IPF disease in general. The study will also
investigate how well GLPG1690 is tolerated (for example if you get any side effects while on
study... expand
The main purpose of this study is to see how GLPG1690 works together with your current standard treatment on your lung function and IPF disease in general. The study will also investigate how well GLPG1690 is tolerated (for example if you get any side effects while on study drug). Type: Interventional Start Date: Nov 2018 |
Treatment Effects on Development of Chemotherapy-Induced Peripheral Neuropathy in Patients With Cancer
Southwest Oncology Group
Anatomic Stage I Breast Cancer AJCC v8
Anatomic Stage IA Breast Cancer AJCC v8
Anatomic Stage IB Breast Cancer AJCC v8
Anatomic Stage II Breast Cancer AJCC v8
Anatomic Stage IIA Breast Cancer AJCC v8
This trial studies treatment effects on development of chemotherapy-induced peripheral
neuropathy in patients with cancer. Treatments for cancer can cause a problem to the nervous
system (called peripheral neuropathy) that can lead to tingling or less feeling in hands and... expand
This trial studies treatment effects on development of chemotherapy-induced peripheral neuropathy in patients with cancer. Treatments for cancer can cause a problem to the nervous system (called peripheral neuropathy) that can lead to tingling or less feeling in hands and feet. Studying certain risk factors, such as age, gender, pre-existing conditions, and the type of treatment for cancer may help doctors estimate how likely patients are to develop the nerve disorder. Type: Observational Start Date: Mar 2019 |
SI-6603 (Condoliase) Study for Lumbar Disc Herniation (Discovery 6603 Study)
Seikagaku Corporation
Lumbar Disc Herniation
This study is to evaluate the effectiveness of a single-dose intervertebral disc injection of
SI-6603 in subjects with lumbar disc herniation (LDH)
expand
This study is to evaluate the effectiveness of a single-dose intervertebral disc injection of SI-6603 in subjects with lumbar disc herniation (LDH) Type: Interventional Start Date: May 2018 |
Randomized Placebo-controlled Trial of FCM as Treatment for Heart Failure With Iron Deficiency
American Regent, Inc.
Heart Failure
Iron-deficiency
The primary objective of this study is to determine the efficacy and safety of iron therapy
using intravenous (IV) ferric carboxymaltose (FCM), relative to placebo, in the treatment of
participants in heart failure with iron deficiency and with a reduced ejection fraction.
expand
The primary objective of this study is to determine the efficacy and safety of iron therapy using intravenous (IV) ferric carboxymaltose (FCM), relative to placebo, in the treatment of participants in heart failure with iron deficiency and with a reduced ejection fraction. Type: Interventional Start Date: Mar 2017 |
Prostate Specific Membrane Antigen (PSMA)-Based PET Imaging of High Risk Prostate Cancer
National Cancer Institute (NCI)
Prostate Cancer
Background:
People with prostate cancer usually have their cancer imaged with a CT scan and bone scan.
They then have their prostate gland removed. Researchers want to test a scan that might
predict if prostate cancer will return after this surgery.
Objective:... expand
Background: People with prostate cancer usually have their cancer imaged with a CT scan and bone scan. They then have their prostate gland removed. Researchers want to test a scan that might predict if prostate cancer will return after this surgery. Objective: To test if a PET/CT scan before the prostate gland is removed can predict if prostate cancer will return. Also, to test if this approach is better or worse than the usual approach for prostate cancer. Eligibility: Men ages 18 and older with prostate cancer that appears to be contained within the prostate but is at risk of having spread Design: Participants will be screened with: - Medical history - Blood tests - CT and MRI scans: Participants will lie in a machine. The machine will take pictures of the body. - Bone scan Participants will have a radiotracer injected into a vein. They will have a PET/CT scan of their whole body 60 90 minutes later. During the scan, they will lie on their back and stay still. Within 60 days after the scan, participants will have surgery. This will remove the prostate gland and lymph nodes around it. Some tissue will be used for genetic testing. If the PET/CT scan suggests the cancer has spread, participants may need to have another biopsy within 60 days after the scan. After surgery, participants will have follow-up visits for 5 years. They will have 5 visits the first year and 2 the second. Then they will have visits once a year. If participants cancer returns, they will have repeat PET/CT scans. Type: Interventional Start Date: Dec 2019 |
Prostate Cancer Outcomes: An International Registry to Improve Outcomes in Men With Advanced Prostate...
Prostate Cancer Clinical Trials Consortium
Prostate Cancer
Our intent is to establish the International Registry to Improve Outcomes in Men with
Advanced Prostate Cancer (IRONMAN) as a prospective, international cohort of minimum 5,000
men with advanced cancer, including men with mHSPC and M0/M1 CRPC. The goal is to establish a
population-based... expand
Our intent is to establish the International Registry to Improve Outcomes in Men with Advanced Prostate Cancer (IRONMAN) as a prospective, international cohort of minimum 5,000 men with advanced cancer, including men with mHSPC and M0/M1 CRPC. The goal is to establish a population-based registry and recruit patients across academic and community practices from Australia, Brazil, Canada, Ireland, Sweden, Switzerland, the United Kingdom (UK), and the US. Target accrual number and number of participating sites are subject to change based on accrual, funding, and interest in participation by other international sites. This cohort study will facilitate a better understanding of the variation in care and treatment of advanced prostate cancer across countries and across academia and community based practices. Detailed data will be collected from patients at study enrollment and then during follow-up, for a minimum of three years. Patients will be followed prospectively for overall survival, clinically significant adverse events, comorbidities, changes in cancer treatments, and PROMs. PROMs questionnaires will be collected at enrollment, every three months for the first and second year then every six months. Physician Questionnaires will be collected from all participating sites at patient enrollment, time of first change in treatment and/or one year follow-up, at each subsequent change of treatment, and discontinuation of treatment. As such, this registry will help identify the treatment sequences or combinations that optimize overall survival and PROMs for men with mHSPC and M0/M1 CRPC. By collecting blood at enrollment, time of first change in treatment and/or one year follow-up (plasma, cell free DNA, buffy coat / RNA), this registry will further identify and validate molecular phenotypes of disease that predict response and resistance to specific therapeutics. Additionally, every effort will be made to collect blood specimen at each subsequent change in treatment. When feasible, existing tumor tissue may be collected for correlation with described blood based studies. All samples will be used for future research. This cohort study will provide the research community with a unique biorepository to identify biomarkers of treatment response and resistance. Type: Observational [Patient Registry] Start Date: Jul 2017 |
Pulmonary Fibrosis Foundation Patient Registry
University of Michigan
Interstitial Lung Disease (ILD)
Idiopathic Pulmonary Fibrosis (IPF)
The Pulmonary Fibrosis Foundation Patient Registry will collect data on at least 2,000
patients with interstitial lung disease (ILD) at approximately 40 clinical sites in the US.
The Registry is targeting enrollment of approximately 60% of the 2,000 ILD participants to
have... expand
The Pulmonary Fibrosis Foundation Patient Registry will collect data on at least 2,000 patients with interstitial lung disease (ILD) at approximately 40 clinical sites in the US. The Registry is targeting enrollment of approximately 60% of the 2,000 ILD participants to have idiopathic pulmonary fibrosis (IPF). The aim of the Registry is to create a cohort of well-characterized patients with interstitial lung disease (ILD) for participation in retrospective and prospective research Type: Observational [Patient Registry] Start Date: Mar 2016 |
CASCARA: Castration Sensitive Carboplatin, Cabazitaxel and Abiraterone
Masonic Cancer Center, University of Minnesota
Prostate Cancer
This is a phase II clinical trial in patients with metastatic castration sensitive prostate
cancer. The objective of the study is to determine the efficacy and further define the safety
of the treatment combination. This study will evaluate dose levels of carboplatin AUC 4 with... expand
This is a phase II clinical trial in patients with metastatic castration sensitive prostate cancer. The objective of the study is to determine the efficacy and further define the safety of the treatment combination. This study will evaluate dose levels of carboplatin AUC 4 with cabazitaxel 20 mg/m2. Patients will be treated with the combination of ADT and carboplatin and cabazitaxel for 6 cycles. After 6 cycles of chemotherapy, they will start abiraterone with ADT. The primary objective is to determine the percent of subjects that have no PSA or radiographic progression at 1 year. Secondary objectives will include determining the progression-free survival, time to PSA nadir and time to PSA progression of carboplatin and cabazitaxel in combination with ADT. Type: Interventional Start Date: Oct 2019 |
Registry Study of COAGADEX® Patients With Moderate or Severe Hereditary Factor X Deficiency Undergoing...
Bio Products Laboratory
Factor 10 Deficiency
This is a non-interventional, multicenter, post-marketing registry study in three patients
with moderate or severe hereditary FX deficiency, to assess Coagadex administered
peri-operatively for hemostatic cover in major surgery during routine post-marketing use.
expand
This is a non-interventional, multicenter, post-marketing registry study in three patients with moderate or severe hereditary FX deficiency, to assess Coagadex administered peri-operatively for hemostatic cover in major surgery during routine post-marketing use. Type: Observational Start Date: Feb 2018 |
The INSPIRE-ASP UTI Trial
Harvard Pilgrim Health Care
Urinary Tract Infection (UTI)
The INSPIRE-ASP UTI trial is a cluster-randomized controlled trial of HCA hospitals comparing
routine empiric antibiotic stewardship practices with real-time precision medicine
computerized physician order entry smart prompts providing the probability that a
non-critically... expand
The INSPIRE-ASP UTI trial is a cluster-randomized controlled trial of HCA hospitals comparing routine empiric antibiotic stewardship practices with real-time precision medicine computerized physician order entry smart prompts providing the probability that a non-critically ill adult admitted with UTI is infected with a resistant pathogen. Note: that enrolled "subjects" represents 59 individual HCA hospitals that have been randomized. Type: Interventional Start Date: Oct 2018 |
Chronic Hypertension and Pregnancy (CHAP) Project
University of Alabama at Birmingham
Hypertension
The purpose of this study is to evaluate whether a blood pressure treatment strategy during
pregnancy to achieve targets that are recommended for non-pregnant reproductive-age adults
(<140/90 mmHg) compared ACOG- recommended standard during pregnancy (no treatment unless BP... expand
The purpose of this study is to evaluate whether a blood pressure treatment strategy during pregnancy to achieve targets that are recommended for non-pregnant reproductive-age adults (<140/90 mmHg) compared ACOG- recommended standard during pregnancy (no treatment unless BP is severe) is effective and safe. Type: Interventional Start Date: Jun 2015 |
Prevention and Treatment Continuum for Youth at HIV Risk, Acutely Infected and With Established HIV Infection
University of California, Los Angeles
Human Immunodeficiency Virus
This is a strategic prospective cohort study which will measure the effects of early
intensive antiretroviral therapy (ART) on the establishment and persistence of HIV-1
reservoirs and HIV-1-specific immunity in acutely /recently HIV infected youth aged 12 to 24
years as compared... expand
This is a strategic prospective cohort study which will measure the effects of early intensive antiretroviral therapy (ART) on the establishment and persistence of HIV-1 reservoirs and HIV-1-specific immunity in acutely /recently HIV infected youth aged 12 to 24 years as compared to newly diagnosed youth with established infection > 6 months. Participants with newly diagnosed acute /recent HIV-1 infection will be offered enrollment into the study with immediate initiation of ART which is the current standard of care. Type: Observational Start Date: Aug 2017 |
ACTIV-2: A Study for Outpatients With COVID-19
National Institute of Allergy and Infectious Diseases (NIAID)
Coronavirus
Covid19
Drug studies often look at the effect one or two drugs have on a medical condition, and
involve one company. There is currently an urgent need for one study to efficiently test
multiple drugs from more than one company, in people who have tested positive for COVID-19
but who... expand
Drug studies often look at the effect one or two drugs have on a medical condition, and involve one company. There is currently an urgent need for one study to efficiently test multiple drugs from more than one company, in people who have tested positive for COVID-19 but who do not currently need hospitalization. This could help prevent disease progression to more serious symptoms and complications, and spread of COVID-19 in the community. This study looks at the safety and effectiveness of different drugs in treating COVID-19 in outpatients. Participants in the study will be treated with either a study drug or with placebo. Type: Interventional Start Date: Aug 2020 |
Safety and Efficacy of Lenvatinib (E7080/MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial...
Merck Sharp & Dohme Corp.
Carcinoma, Hepatocellular
The purpose of this study is to evaluate the efficacy and safety of lenvatinib and
pembrolizumab in combination with TACE versus TACE plus oral and intravenous (IV) placebos in
participants with incurable, non-metastatic hepatocellular carcinoma (HCC). The primary
hypotheses... expand
The purpose of this study is to evaluate the efficacy and safety of lenvatinib and pembrolizumab in combination with TACE versus TACE plus oral and intravenous (IV) placebos in participants with incurable, non-metastatic hepatocellular carcinoma (HCC). The primary hypotheses are that pembrolizumab plus lenvatinib in combination with TACE is superior to placebo plus TACE with respect to progression-free survival (PFS) and overall survival (OS). Type: Interventional Start Date: May 2020 |